DR3/TRAMP Antibody

Tumor necrosis factor receptor superfamily member 25 (TRAMP/DR3 or Apoptosis-mediating receptor DR3) is the receptor for TNFSF12/APO3L/TWEAK. TRAMP interacts directly with the adapter TRADD. TRAMP mediates activatio of NFkB and induces apoptosis. TRAMP/DR3 plays a role in regulating lymphocyte homeostasis. TRAMP/DR3 forms homodimers to interact strongly via the death domains with TNFRSF1 and TRADD to activate the apoptosis and NFkB signaling cascades. DR3 is highly expressed in thymocytes and lymphocytes.