DR3/Apo3 Polyclonal Ab
- 貨號 Cat. No.
- 3057-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= //p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN:/strong Synthetic peptide corresponding to residues surrounding amino acids 400 of human DR3.br /
strongbr /
SPECIES REACTIVITY: /stronghuman, mouse, rat br /
br /
strongFORMULATION:/strong br /
100 ug (0.5 mg/ml) antigen affinity-purified rabbit anti-DR3/Apo3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.br /
br /
strongSTORAGE CONDITIONS: /strongbr /
Store at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION:/strong br /
Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.br /
br /
strongSPECIFICITY:/strongbr /
The antibody detects a ~59 kDa protein, corresponding to the apparent molecular weight of DR3 on SDS-PAGE immunoblots. br /
br /
strongAPPLICATION AND USAGE:/strong br /
The antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in humans.br /
/strong/font/p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN:/strong Synthetic peptide corresponding to residues surrounding amino acids 400 of human DR3.br /
strongbr /
SPECIES REACTIVITY: /stronghuman, mouse, rat br /
br /
strongFORMULATION:/strong br /
100 ug (0.5 mg/ml) antigen affinity-purified rabbit anti-DR3/Apo3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.br /
br /
strongSTORAGE CONDITIONS: /strongbr /
Store at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION:/strong br /
Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.br /
br /
strongSPECIFICITY:/strongbr /
The antibody detects a ~59 kDa protein, corresponding to the apparent molecular weight of DR3 on SDS-PAGE immunoblots. br /
br /
strongAPPLICATION AND USAGE:/strong br /
The antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in humans.br /
/strong/font/p