DPP4 Activity Fluorometric Assay Kit
Kits
- 貨號 Cat. No.
- K779-100
- 規格 Size
- K779-100
- Sample Type
- Cell and tissue culture lysates 、 cell culture medium 、 etc.) 、 Other biological fluids 、 Plasma 、 Serum
Description
Alternate Name :
Tag Line :
Highly Sensitive Assay, HTS
Storage Conditions: -20°C
Shelf life: 12 months
Summary :
• Detection method- Fluorescence (Ex/Em 360/460 nm)
• Species reactivity- Mammalian
• Applications- This kit detects DPP4 activity as low as 3 µU per well.
Detection Method:
Features & Benefits:
Description:
Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. The substrates of CD26/DPP4 are proline (or alanine) containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1 and hence its inhibition by drugs such as Sitagliptin have been used for treatment of diabetes mellitus type 2. DPP4 also appears to work as a suppressor in the development of cancer and tumors. In BioVision’s DPP4 Activity Assay Kit, DPP4 cleaves a substrate to release a quenched fluorescent group, AMC (7-Amino-4-Methyl Coumarin), (Ex/Em = 360/460 nm). This assay is rapid, simple, sensitive, and reliable, as well as, suitable for high throughput activity screening of DPP4. This kit detects DPP4 activity as low as 3 µU per well.