DJ-1 Antibody

Protein DJ-1 (DJ-1) protects cells against oxidative stress and cell death. DJ-1 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. DJ-1 eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. DJ-1 acts as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide.