Dexamethasone

Alternate Name/Synonyms: 9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione

Appearance: White solid

Formulation: N/A

CAS Number: 50-02-2

Molecular Formula: C₂₂H₂₉FO₅

Molecular Weight: 392.46

Purity: >99% by TLC

Solubility: DMSO ( 25 mg/ml) or EtOH

Storage Temp.: -20°C

Shipping Conditions: RT

Description: An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (ICâ‚…â‚€ = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C

Handling: Protect from light and moisture