- 貨號 Cat. No.
- D-400
- 規格 Size
- 70 μg 5x70 μg
Description
Dendrotoxin-K
A Potent Blocker of KV1.1 Channels
Sequence: |
AAKYC KLPLR IGPCK RKIPS FYYKW KAKQC LPFDY SGCGG NANRF KTIEE CRRTC VG |
Bioassay: |
100 nM Dendrotoxin-K, was potent in blocking Kv1.1 channels (87?%, n=4), but Blocked only 55?%, (n=4) of cloned Kv1.2 channels currents expressed in Xenopus oocytes (Figure 1).
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Kv1.1 (left, in 2mM K+) and Kv1.2 (right, in 5mM K+) channel currents, elicited by 200 ms depolarization from holding potential of ?00 mV to +20 mV, before and during application of 100 nM Dendrotoxin-K.
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1.
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Schweitz, H. et al. (1990) Toxicon 28, 847. |
2.
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Wang, F. C. et al. (1999) Eur. J. Biochem. 263, 222. |
3.
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Owen, D. G. et al. (1997) Br. J. Pharmacol. 120, 1029. |
4.
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Southan, A. P. and Robertson, B. (1998) Br. J. Pharmacol. 125, 1375. |
Dendrotoxin-K is isolated from Dendroaspis p.polylepis snake venom, by modification of the procedure of Schweitz1 and purified to homogeneity. It blocks mainly Kv1.1 (EC50=0.6 nM2) but also Kv1.2 channels (see below).
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