Dendrotoxin-I
- 貨號 Cat. No.
- D-390
- 規格 Size
- 0.14 mg 5x0.14mg
Description
Dendrotoxin-I
A Potent Blocker of Kvv1.1 and Kv1.2 Channels
| Product#: | D-390 |
| Sizes: |
| 0.14 mg |
| 5 x 0.14 mg |
| M.W.: | 7149 |
| Sequence: | QPLRK LCILH RNPGRCYQKI PAFYYNQKKK QCEGFTWSGC GGNSNRFKTI EECRRTCIRK |
| Purity: | >98% |
| Bioassay: |
100 nM Dendrotoxin-I blocked 92?% (n=4) and 84?% (n=4) of cloned Kv1.1 and Kv1.2 channels currents expressed in Xenopus oocytes. |
 |
| Kv1.1 (left, in 2mM K+) and Kv1.2 (right, in 5mM K+) channel currents, elicited by 200 ms depolarization from holding potential of -100 mV to +20 mV, before and during application of 100 nM Dendrotoxin-I. |
| References: |
1. | Schweitz, H. et al. (1990) Toxicon 28, 847. |
2. | Hopkins, W. F. (1998) J. Pharmacol. Exp. Therap. 285, 1051. |
3. | Harvey, A. L. (2001) Toxicon 39, 15. |
Dendrotoxin-I is isolated from Dendroaspis p.polylepis snake venom, by modification of the procedure of Schweitz1 and purified to homogeneity.
Dendrotoxin-I blocks Kv1.2 and Kv1.1 channels (IC50=0.13 and 3.1 nM in oocytes respectively, with higher values for mammalian cells)3 as well as heteromultimeric channels containing these, with other Kv1 isoforms2 (for review see3).