Deltarasin
Chemical Compounds
- 貨號 Cat. No.
- M3394
- 規格 Size
- 5mg,10mg,50mg
- 品牌 Brand
- No Brand
Description
Deltarasin inhibits the interaction of RAS with PDEδ with KD of 41 nM. Deltarasin selectively binds to the prenyl-binding pocket of PDEδ with nanomolar affinity (IC50 = 41 nM, binding to PDEδ in cell). Deltarasin was tested as an inhibitor in mice that had previously received injections of human tumor cells with KRAS mutations. Deltarasin was effective as an inhibitor in sharply reducing tumor growth in comparison to a placebo.
