DcR3 Protein, Human, Recombinant (Fc Tag)

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also
known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor
receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis
factor receptor superfamily. The encoded protein is postulated to play a
regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts
as a decoy receptor that competes with death receptors for ligand binding.
Over-expression of this gene has been noted in gastrointestinal tract
tumors. Read-through transcription into this gene from the neighboring
upstream gene, which encodes regulator of telomere elongation helicase 1
(RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected
in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult
stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This
protein is highly expressed in several primary tumors from colon, stomach,
rectum, esophagus and in SW480 colon carcinoma cells.