DcR3 Polyclonal Antibody
- 貨號 Cat. No.
- 3213-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/3213.gif alt= //p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 34 of human DcR3 precursor/p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-DcR3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bApoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was also recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues./p
pbAPPLICATION AND USAGE: /bDetects 33 kDa DcR3 by Western blot analysis (0.5-4 ug/ml). Human heart tissue lysate can be used as positive control. Other applications have not been tested./p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 34 of human DcR3 precursor/p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-DcR3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bApoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was also recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues./p
pbAPPLICATION AND USAGE: /bDetects 33 kDa DcR3 by Western blot analysis (0.5-4 ug/ml). Human heart tissue lysate can be used as positive control. Other applications have not been tested./p