DcR1 Polyclonal Antibody
- 貨號 Cat. No.
- 3212-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= /nbsp;/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residues surrounding amino acid 152 of human DcR1./p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbFORMULATION: /b100 ug (0.5 mg/ml) immunoaffinity purified rabbit anti-DcR1 polyclonal antibody in 0.01% thimerosal, 30% glycerol and 0.5%BSA./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT AND DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-4 ug/ml) and immunofluorescence. However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe antibody detects an approximately 65 kDa DcR1 by Western blot analysis. HeLa cell lysate can be used as a positive control. FOR RESEARCH USE ONLY! Not to be used in human subjects./p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residues surrounding amino acid 152 of human DcR1./p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbFORMULATION: /b100 ug (0.5 mg/ml) immunoaffinity purified rabbit anti-DcR1 polyclonal antibody in 0.01% thimerosal, 30% glycerol and 0.5%BSA./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT AND DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-4 ug/ml) and immunofluorescence. However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe antibody detects an approximately 65 kDa DcR1 by Western blot analysis. HeLa cell lysate can be used as a positive control. FOR RESEARCH USE ONLY! Not to be used in human subjects./p