Daxx Polyclonal Ab
- 貨號 Cat. No.
- 3123-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= //p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 725 of human DAXX/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-Daxx polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse, monkey/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND DESCRIPTION: /bApoptosis can be induced by certain cytokines including TNF and Fas ligand through binding to their respective death domain (DD) containing receptors, TNFR1 and Fas. Cell death signals can then be transduced by DD-containing adapter molecules and members of the caspase family. A novel DD-containing adapter molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds to the Fas DD and activates a FADD-independent death pathway that involves the stress activated c-Jun NH2-terminal kinase (JNK). Daxx activates the JNK kinase kinase ASK1 that is also known as MAPKKK5. FADD and Daxx activate two independent pathways downstream of Fas. Daxx mRNA is widely expressed in fetal and adult tissues with the highest amounts being found in the testis./p
pbSPECIFICITY: /bThe antibody recognizes ~120 kDa Daxx in SDS-PAGE immunoblots. The predicted molecular weight for Daxx is 82 kDa. The difference in molecular weight may be due to a high content of acidic residues. HeLa cell lysate can be used as a positive control./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-2 ug/ml). However, the optimal conditions should be determined individually. Other applications have not been tested./p
pbFOR RESEARCH USE ONLY! Not to be used in human. /b/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 725 of human DAXX/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-Daxx polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse, monkey/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND DESCRIPTION: /bApoptosis can be induced by certain cytokines including TNF and Fas ligand through binding to their respective death domain (DD) containing receptors, TNFR1 and Fas. Cell death signals can then be transduced by DD-containing adapter molecules and members of the caspase family. A novel DD-containing adapter molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds to the Fas DD and activates a FADD-independent death pathway that involves the stress activated c-Jun NH2-terminal kinase (JNK). Daxx activates the JNK kinase kinase ASK1 that is also known as MAPKKK5. FADD and Daxx activate two independent pathways downstream of Fas. Daxx mRNA is widely expressed in fetal and adult tissues with the highest amounts being found in the testis./p
pbSPECIFICITY: /bThe antibody recognizes ~120 kDa Daxx in SDS-PAGE immunoblots. The predicted molecular weight for Daxx is 82 kDa. The difference in molecular weight may be due to a high content of acidic residues. HeLa cell lysate can be used as a positive control./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-2 ug/ml). However, the optimal conditions should be determined individually. Other applications have not been tested./p
pbFOR RESEARCH USE ONLY! Not to be used in human. /b/p