DAP3 Polyclonal Antibody
- 貨號 Cat. No.
- 3263-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= //p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 60 of human DAP3./p
pbSPECIES REACTIVITY: /bhuman/p
pbFORMULATION: /b100 ug (0.2 mg/ml) affinity purified rabbit anti-DAP3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND DESCRIPTION: /bDeath Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-? and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe antibody detects 46 kDa human DAP3. It does not cross-react with other DAP family members. FOR RESEARCH USE ONLY! Not to be use din humans./p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 60 of human DAP3./p
pbSPECIES REACTIVITY: /bhuman/p
pbFORMULATION: /b100 ug (0.2 mg/ml) affinity purified rabbit anti-DAP3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND DESCRIPTION: /bDeath Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-? and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe antibody detects 46 kDa human DAP3. It does not cross-react with other DAP family members. FOR RESEARCH USE ONLY! Not to be use din humans./p