DAP12 Polyclonal Antibody
- 貨號 Cat. No.
- 5570-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/5570.gif alt= /nbsp;/p
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b E. coli-expressed rat DAP12/p
pbSPECIES REACTIVITY:/b rat/p
pbFORMULATION:/b 100 ug (0.5 mg/ml) affinity purified rabbit anti-rat DAP12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pDAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation./p
pbDESCRIPTION:/b/p
pbAPPLICATION AND SPECIFICITY/b The antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually./p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b E. coli-expressed rat DAP12/p
pbSPECIES REACTIVITY:/b rat/p
pbFORMULATION:/b 100 ug (0.5 mg/ml) affinity purified rabbit anti-rat DAP12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pDAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation./p
pbDESCRIPTION:/b/p
pbAPPLICATION AND SPECIFICITY/b The antibody can be used for Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually./p