Dacarbazine

Dacarbazine (also known as DIC or Imidazole Carboxamide) is a triazine antineoplastic agent. Dacarbazine is a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group to its DNA. Dacarbazine has significant activity against melanomas. Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis. Dacarbazine is used as an antineoplastic in the treatment of malignant melanoma and sarcomas.