Cytochalasin E

貨號 Cat. No.: C-550
規格 Size: 10 x 0.1 mg 1mg 5x1mg

Description

Cytochalasin E

Protein Synthesis and Transport Inhibitor

Product#:

C-550

Sizes:

10 x 0.1 mg

1 mg

5 x 1 mg

M.W.:

495.6

CAS No.:

[36011-19-5]

Structure:

Purity:

>99%

Bioassay:

Cytochalasin E inihibits actin polymerization in C6 cells.

C6 glioma cells were incubated in presence (B) or absence (A) of 10 mM Cytochalasin E (#C-550) for 60 min at 37oC.

The picture represent dual staining superposition of fluorescence micrographs

using Rhodamine conjugated - palloidine (red, for actin filaments staining) and

Dapi for nucleus staining (blue).

References:

1.	Smith, G.F. et al. (1967) Nature 216, 1134.
2.	Tellam, R. and Frieden, C. (1982) Biochemistry 21, 3207.
3.	Yahara, I. et al. (1982) J. Cell Biol. 92, 69.
4.	Matsuyama, T. et al. (1991) J. Immunol. 146, 3736.
5.	McDonald, T.P. et al. (1995) J. Biol. Chem. 270, 30359.
6.	Baeker, T.R. et al. (1987) J. Immunol. 138, 2691.

Cytochalasins are a group of fungal toxin metabolites which bind to actin and alter its polymerization. Cytochalasins bind to the barbed end of actin filament and prevent both the association and dissociation of actin subunits, by inhibiting cell microtubule formation, cell division and cell migration.^1-4 Cytochalasin E induced a rapid and sustained elevation of intracellular free Ca²⁺ in B lymphocytes by increasing the extracellular Ca²⁺ influx.^5,6

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