CYT387
Chemical Compounds
- 貨號 Cat. No.
- M1700
- 規格 Size
- 10mg,50mg, 200mg
- 品牌 Brand
- No Brand
Description
CYT387 is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. CYT387 inhibits growth of Ba/F3-JAK2V617F and human erythroleukemia (HEL) cells (IC (50) approximately 1500 nM) or Ba/F3-MPLW515L cells (IC (50)=200 nM), but has considerably less activity against BCR-ABL harboring K562 cells (IC50=58000 nM).
