Cynomolgus IL-31 Protein, His Tag

Source : 

Cynomolgus IL-31, His Tag (IL1-C5245) is expressed from human 293 cells (HEK293). It contains AA Leu 27 - Thr 163 (Accession # G7PJ78-1).

 

Molecule : IL-31

 

Synonyms : IL-31,IL31,Interleukin-31

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 17.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.3 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

 

References :

(1) Cornelissen C, et al. Eur J Cell Biol. 2012. 91(6-7):552-66.
(2) Zhang Q, et al. Cytokine Growth Factor Rev. 2008. 19(5-6):347-56.
(3) Dillon SR, et al. Nat Immunol. 2004. 5(7):752-60.