Cynomolgus B7-H6 / NCR3LG1 Protein

Source : 

Cynomolgus B7-H6 (B76-C52Ha) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Asp 259 (Accession # XP_005578557.1).

 

Molecule : B7-H6

 

Synonyms : B7-H6,NCR3LG1,B7 Homolog 6

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : XP_005578557.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 28.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome.
Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.

 

References :

(1) Wu MR, et all., 2015, Gene Ther. 22(8):675-84.
(2) Phillips M, et all., 2016, Biopolymers. 106(5):658-72.
(3) Flajnik MF, et all., 2012 Immunogenetics. 64(8):571-90.