Antibodies
Cyclophosphamide
- 貨號 Cat. No.
- S1217
- 規格 Size
- 5~200mg
- 品牌 Brand
- Selleckchem
Description
Cyclophosphamide
Cyclophosphamide is a nitrogen mustard alkylating agent from the oxazophorines group.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | Cyclophosphamide is a nitrogen mustard alkylating agent from the oxazophorines group. | |||||
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| In vitro | Cyclophosphamide is an alkylating agent with cytotoxic and immunosuppressive activities. Cyclophosphamide requires enzymatic and chemical activation to release active phosphoramide mustard which produces the interstrand and intrastrand DNA crosslinks at guanine N-7 positions. Cyclophosphamide exerts its cytotoxic activity by inhibiting nuclear DNA replication. The mechanism of Cyclophosphamide -induced immunosuppression is possibly due to direct cytotoxic effect of the drug on immunocompetent lymphocytes, particulafly those that have undergone antigenic differentiation and division. Cyclophosphamide has its greatest effect on B cells with relative T cell-sparing effect. [1] Trials in various tumor-bearing animals confirmed this in vivo activity and demonstrated fairly potent antitumor effect. Cyclophosphamide, in combination with other antineoplastic agents, is used for the treatment of various cancers, including breast, lymphoid and pediatric malignancies. [2] | |||||
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Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 261.09 |
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| Formula | C7H15Cl2N2O2P |
| CAS No. | 50-18-0 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane |
| Solubility (25°C) * | In vitro | DMSO | 52 mg/mL (199 mM) |
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| Water | 43 mg/mL (164 mM) | ||
| Ethanol | 52 mg/mL (199 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
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| Mass(mg) | 0.26109 | 2.6109 | 5.2218 | 7.8327 |
Customer Reviews (1)
 Click to enlarge | Rating | |
| Source | Cancer Res, 2012, 72(23):6200-8. Cyclophosphamide purchased from Selleck | |
| Method | colorimetry | |
| Cell Lines | Conditional patched mutant tumor cells | |
| Concentrations | ||
| Incubation Time | 48 h | |
| Results | Plk inhibitor cooperates with cyclophosphamide. |
Product Citations (1)
