Cyclopamine

Alternate Name/Synonyms: 11-deoxojervine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 4449-51-8

Molecular Formula: C₂₇H₄₁NO₂

Molecular Weight: 411.62

Purity: ≥99%

Solubility: DMSO (4 mg/ml) and EtOH (5 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins.  Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

Handling: Teratogen!