Cycloheximide

貨號 Cat. No.: C-850
規格 Size: 100 mg 5x100 mg 10x100 mg 1 gram

Description

Cycloheximide

Product#:

C-850

Sizes:

100 mg

5 x 100 mg

10 x 100 mg

1 gram

Cycloheximide acts as an elongation inhibitor during protein synthesis in eukaryotes but not prokaryotes by competition with the binding of ATP to the 60S ribosomal subunit. Mutations in the yeast gene CYH2 that encode to L29, a component of the 60S ribosomal subunit, can lead to Cycloheximide resistance.^3-6

M.W.:

281.3

CAS No.:

[66-81-9]

Structure:

Purity:

>98%

Bioassay:

Cycloheximide inhibits the synthesis of green fluorescent protein (GFP).

293-HEK cells were transiently transfected with GFP for 18 h followed

by treatment without (A) or with (B) 100 mM Cycloheximide. 24h later

the cells were visualized with fluorescent microscopy.

References:

1.	Dewitte-Orr, S.J. et al. (2005) Fish. Shell. Immunol. 18, 279.
2.	Wool, I.G. and Cavicchi, P. (1966) PNAS 56, 991.
3.	Lin, W. and Hsu, Y. (2000) Cell Signal 12, 457.
4.	Marcus, P.I. and Salb, J.M. (1966) Cold Spring Harb. Symp. Quant. Biol. 31, 335.
5.	Georg, L.K. (1953) AMA Arch. Derm. Syphilol. 67, 355.
6.	Kaufer N.F. et al. (1983) Nucleic Acids Res. 11, 3123

Cycloheximide is an antibiotic, which is primary used for the isolation of dermatophytes from clinical materials.^1,2 It induces death of eukaryote cells in an apoptosis-independent pathway.

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