Cyclin O Antibody

Cyclin O (CCNO) has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to intrinsec apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Suppression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. This protein was previously called UNG2 after being erroneously identified as a uracil DNA glycolase, but later identified as a cyclin protein family member. This antibody binds to the two isoforms of Cyclin O.