CUDC-101
Chemical Compounds
- 貨號 Cat. No.
- M1693
- 規格 Size
- 10mg,50mg, 200mg
- 品牌 Brand
- No Brand
Description
CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 synergistically blocked key regulators of EGFR/HER2 signaling pathways, also attenuating multiple compensatory pathways, such as AKT, HER3, and MET, which enable cancer cells to escape the effects of conventional EGFR/HER2 inhibitors.
