CRLF2 Antibody

Cytokine Receptor-Like Factor 2 (CRLF2 or TSLPR) is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP. The CRLF2 contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. CRLF2 has a predicted molecular weight approximately 41 kDa, and two further isoforms have been reported that are produced by alternative splicing. CRLF2 is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.