CP-690550

Alternate Name/Synonyms: Tasocitinib

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 477600-75-2

Molecular Formula: C₁₆H₂₀N₆O

Molecular Weight: 312.37

Purity: ≥99% by HPLC

Solubility: DMSO (100 mg/ml) of EtOH (100 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: CP-690550 treatment of murine factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring human wild-type or V617F JAK2 resulted in inhibition of cell proliferation with an ICâ‚…â‚€ of 2.1 µM and 0.25 µM, respectively. Furthermore, CP-690550 treatment of ex-vivo-expanded erythroid progenitors from JAK2(V617F)-positive PV patients resulted in specific, antiproliferative (ICâ‚…â‚€ = 0.2 µM) and pro-apoptotic activity.

Handling: Protect from air and moisture