COX-2 Inhibitor Screening Kit (Fluorometric)

Alternate Name : Prostaglandin-Endoperoxide Synthase 2 Inhibitor Screening Kit (Fluorometric), PTGS2 Inhibitor Screening Kit (Fluorometric)

Tag Line :

Simple assay to screen/study/characterize COX-2 Inhibitors

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection method- Fluorescence (Ex/Em = 535/587 nm)
• Applications- Screening/studying/characterizing COX-2 inhibitors.

Detection Method: Fluorescence (Ex/Em = 535/587 nm)

Features & Benefits:

• Simple method to screen COX-2 inhibitors
• High-throughput
• Includes Inhibitor Control, Celecoxib

Description:

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain. BioVision’s COX-2 Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of COX-2 inhibitors. The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.