Compound 401

Alternate Name/Synonyms: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 168425-64-7

Molecular Formula: C₁₆H₁₅N₃O₂

Molecular Weight: 281.31

Purity: ≥97% by HPLC

Solubility: DMSO (10 mM) or EtOH (5 mM)

Storage Temp.: +4°C

Shipping Conditions: RT

Description: Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (ICâ‚…â‚€ = 0.28 µM) that also targets mTOR (IC50 = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.

Handling: Protect from air and light