Antibodies
CNX-774
- 貨號 Cat. No.
- S7257
- 規格 Size
- 10mgã€50mg
- 品牌 Brand
- Selleckchem
Description
CNX-774
Catalog No.S7257
CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM. | |||||
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| Targets | BTK | |||||
| IC50 | <1 nM [1] | |||||
| In vitro | In cellular assays, CNX-774 demonstrates potent inhibitory activity towards BTK with IC50 of 1-10 nM by targeting Cys-481 residue within the ATP binding site of the enzyme. [1] | |||||
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| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 499.5 |
|---|---|
| Formula | C26H22FN7O3 |
| CAS No. | 1202759-32-7 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 100 mg/mL (200 mM) |
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| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 2 mg/mL (4 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide |
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