Clodronate disodium

Clodronate disodium is a first generation (non-nitrogenous) bisphosphonate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. Additionally, Clodronate demonstrates the ability to cause a collapse of the mitochondrial membrane potential which eventually results in osteoclast apoptosis. Clodronate is also used in experimental medicine to selectively deplete macrophages.