Clemizole

Clemizole is a H1 histamine receptor antagonist. clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive.