Clasto-lactacystin β-lactone
- 貨號 Cat. No.
- I-100
- 規格 Size
- 200 μg
- 品牌 Brand
- Boston Biochem
Description
Clasto-lactacystin β-lactone
Product Information
200 μg
95% by HPLC. Structure confirmed by 1H-NMR.
Soluble up to 20 mg/ml and stable in DMSO, MeCN. Subject to hydrolysis in aqueous buffers. Pellet dry compound by centrifugation prior to DMSO addition. Store at -20°C. Avoid multiple freeze/thaw cycles.
kobs / [I] = 20,000 M-1 s-1 vs. 20S:PA28 complex. Inhibits ubiquitin proteasome pathway in cell culture (IC50=1 μM).
Catalog #: I-100
Clasto-lactacystin β-lactone
Product Source:
Synthetic
Potent, highly specific, irreversible and cell-permeable inhibitor that covalently modifies the catalytic β subunits of the proteasome. The β-lactone intermediate is generated from the aqueous hydrolysis of lactacystin, and is the active inhibitory species that reacts with the proteasome.
Product Information
Quantity:
200 μg
Structure:
Purity:
95% by HPLC. Structure confirmed by 1H-NMR.
Solubility:
Soluble up to 20 mg/ml and stable in DMSO, MeCN. Subject to hydrolysis in aqueous buffers. Pellet dry compound by centrifugation prior to DMSO addition. Store at -20°C. Avoid multiple freeze/thaw cycles.
Activity:
kobs / [I] = 20,000 M-1 s-1 vs. 20S:PA28 complex. Inhibits ubiquitin proteasome pathway in cell culture (IC50=1 μM).