Chymotrypsin activity photometric

Chymotrypsin is a pancreas specific proteolytic enzyme. It is produced in the pancreas
and excreted in the small intestine. Chymotrypsin is involved in exocrine pancreas
insufficiency in the case of a chronic pancreatitis. The detection of chymotrypsin
in stool is a strong, indicative parameter for pancreas function disorder and
has the advantage of only requiring a non-invasive sampling. The time, effort and
expense in a chymotrypsin determination is significantly low when compared to the
pancreolauryl or pancreozymin-secretin test.
The chymotrypsin activity can be determined with our spectral-photometric chymotrypsin
test. Patients with digestive disturbances as a result of pancreas function
disorder are often supplemented with pancreatic enzymes. Such medication must
be discontinued at least 5 days before the stool sample is collected. Laxatives should
also not be taken before the sample collection. False low chymotrypsin activity levels
can be expected in the case of diarrhoea, low-protein diet or obstructive jaundice,
whereas false normal level by non-discontinued enzyme substitution. Very high levels
are indicative of a fermentation or an increased intestinal fluid secretion (e.g. by
enterocolitis).