CHIR 99021

Alternate Name/Synonyms: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021

Appearance: Off-white solid

Formulation: N/A

CAS Number: 252917-06-9

Molecular Formula: C₂₂H₁₈Cl₂N₈

Molecular Weight: 465.34

Purity: ≥98% by HPLC

Solubility: DMSO ( 100 mM)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (ICâ‚…â‚€ = 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.

Handling: Protect from air and moisture