Cerebellin Peptide

Cerebellin is a 16-amino acid peptide originally isolated from rat cerebellum, which actually comes from precerebellin (cerebellin-1) processing into cerebellin and [des-Ser1]-cerebellin. Cerebellin is widely distributed in the central nervous system, where it exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.