CD79a Antibody

h1 class=titleCD79a Antibody/h1
div id=node-1902 class=node ntype-antibodiesRabbit Polyclonal, HRP-conjugated
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h4Catalog Number/h4
pstrong252258/strong/p
h4Unit/h4
pstrong0.1 mg /strong/p
h4Isotype/h4
Rabbit Ig
h4Applications/h4
E, WB, IHC
h4Species reactivity/h4
H
h4Format/h4
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pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe CD79a antigen (Immunoglobulin binding protein-1, IGBP-1) is an alpha/beta heterodimer cell membrane protein required in cooperation with CD79b for the initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR). This cascade leads to BCR complex internalization, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and efficient differentiation of pro- and pre-B-cells. CD79a interacts with numerous kinases such as SYK, BLNK, Src-family tyrosine kinases. Defects in CD79a are a cause of non-Bruton type agammaglobulinemia, an immunodeficiency disease of the B-cell maturation pathway./p
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h4Alternate Names/h4
pCD79A; IGBP-1; Immunoglobulin binding protein-1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Surface IgM-associated protein; Membrane-bound immunoglobulin-associated protein/p
h4Accession No./h4
pa class=accession-link href=http://www.expasy.ch/uniprot/P11912 target=_blankP11912/abr /
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD79a./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:100-1:500/p
pIHC: 1:100-1:500/p
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h4Storage/h4
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pStore at -20deg;C. Product is guaranteed 6 months from the date of shipment./p
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