CD79a Antibody

Catalog Number

252272

Unit

0.1 mg

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

The CD79a antigen (Immunoglobulin binding protein-1, IGBP-1) is an alpha/beta heterodimer cell membrane protein required in cooperation with CD79b for the initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR). This cascade leads to BCR complex internalization, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and efficient differentiation of pro- and pre-B-cells. CD79a interacts with numerous kinases such as SYK, BLNK, Src-family tyrosine kinases. Defects in CD79a are a cause of non-Bruton type agammaglobulinemia, an immunodeficiency disease of the B-cell maturation pathway.

Alternate Names

CD79A; IGBP-1; Immunoglobulin binding protein-1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Surface IgM-associated protein; Membrane-bound immunoglobulin-associated protein

Accession No.

P11912

 

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD79a.

Application Notes

IF: 1:20-1:100

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.