CD62P (HI62P) Antibody

h1 class=titleCD62P (HI62P) Antibody/h1
div id=node-1861 class=node ntype-antibodiesMouse Monoclonal, PE-conjugated, APC-conjugated
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h4Catalog Number/h4
pstrong251090/strong/p
h4Unit/h4
pstrong2 ml/strong/p
h4Format/h4
pEach vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCD62P antibody recognizes a 140KD long single chain type I transmembrane glycoprotein, P-selectin, also called Granule membrane protein-140 (GMP-140) or platelet activation dependent granule-external membrane protein (PADGEM). CD62P antigen is present in the alpha;-granules of platelets and in Weibel-palade bodies of endothelial cells, and is rapidly mobilized from storage granules to the cell surface after cell activation. So, CD62P is expressed on the surface of the activated platelets. Interaction of CD62P with PSGL-1 (CD162) mediates tethering and rolling of leucocytes on the surface of activated endothelial cells, the first step in leucocyte extravasations and migration towards sites of inflammation. CD62P also mediates rolling of platelets on endothelial cells and CD62P-mediated interactions are also involved in platelet-mediated delivery of lymphocytes to high endothelial venules (HEV)./p
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h4Alternate Names/h4
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h4Accession No./h4
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h4Clonality/h4
pHI62P/p
h4Antigen/h4
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h4Application Notes/h4
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pFACS with whole blood: 100 mu;l blood + 20 mu;l antibody; FACS with cells: 10E6 cells + 20 mu;l antibody. E: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pIF:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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