CD62P Antibody

CD62P (P-Selectin) is a Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. CD62P mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand for CD62P is sialyl-Lewis X. Activation of CD62P mediates leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in CD62P have been linked to an increased susceptibility to ischemic stroke.