CD57 (HI57a) Antibody

h1 class=titleCD57 (HI57a) Antibody/h1
div id=node-1858 class=node ntype-antibodiesMouse Monoclonal, PE-conjugated
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h4Catalog Number/h4
pstrong251086/strong/p
h4Unit/h4
pstrong2 ml/strong/p
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Format/h4
pEach vial contains 2 ml IgM (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by hydroxyapatite chromatography./p
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h4Description/h4
pCD57 antibody recognizes a 110-115KD carbohydrate antigen called HNK-1. HNK-1 is not a specific marker for NK cells, being shared by calls belonging to different lineages. CD57 antigen is expressed on 12-20% of normal peripheral blood lymphocytes including a subset of NK cells and a subset of CD8+ Ts/Tc, and the expression increases with relation to age in peripheral blood lymphocytes, such as 25-40% in over 80 years. CD57 is not expressed by cord blood lymphocytes, B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. CD57+ cells also increase in some pathologies characterized by an imbalance of CD4/CD8 lymphocytes, e.g., AIDS, autoimmune diseases, allograft transplants, viral infections. The CD57 molecule is shared by normal neural and striated muscle and their neoplastic counterparts including neurofibromas, neurofibrosarcomas and malignant melanomas. CD57 is also present on normal and neoplastic prostatic epithelia, where it represents a prognostic factor showing a positive correlation between the number of CD57+ cells and an increased survival of the neoplastic patients./p
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h4Product Citations/h4
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pTadamitsu K, K.Hitoshi, A.E.G.Kr.van dem Borne, et al., eds. 1997. Leucocyte Typing â…¥: White Cell Differentiation Antigens. Garland Publishing, Inc; New York./p
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h4Recommended Products/h4
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h4Alternate Names/h4
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h4Accession No./h4
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h4Clonality/h4
pHI57a/p
h4Antigen/h4
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h4Application Notes/h4
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pFACS with whole blood: 100 mu;l blood + 20 mu;l antibody; FACS with cells: 10E6 cells + 20 mu;l antibody. E: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pIF:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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