CD42b (HIP1) Antibody

h1 class=titleCD42b (HIP1) Antibody/h1
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h4Catalog Number/h4
pstrong251078/strong/p
h4Unit/h4
pstrong2 ml/strong/p
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Format/h4
pEach vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCD42b antibody recognizes a glycoprotein, heterodimer (GPIbalpha;) which contains an alpha; chain (CD42b, 145KD) and a beta; chain (CD42c, 22KD) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. This antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). HIP1 antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation./p
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h4Product Citations/h4
pnbsp;/p
pChen Z., Bao ZX., Yu AX., et al ; 1987. Anbsp; group monoclonal antibodies against human platelets with different functions. Chinese Science Bulletin. 24:1902/p
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h4Recommended Products/h4
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h4Alternate Names/h4
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h4Accession No./h4
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h4Clonality/h4
pHIP1/p
h4Antigen/h4
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h4Application Notes/h4
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pFACS with whole blood: 100 mu;l blood + 20 mu;l antibody; FACS with cells: 10E6 cells + 20 mu;l antibody. E: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pIF:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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