CD41 (HIP8) Antibody

h1 class=titleCD41 (HIP8) Antibody/h1
div id=node-1851 class=node ntype-antibodiesMouse Monoclonal, PE-conjugated
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h4Catalog Number/h4
pstrong251074/strong/p
h4Unit/h4
pstrong2 ml/strong/p
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pnbsp;/p
Format/h4
pEach vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
pnbsp;/p
h4Data and Images/h4
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h4Description/h4
pCD41 antibody recognizes a 140KD glycoprotein which is the alpha; subunit of the CD41/CD61 (GPIIb/IIIa, alpha;IIbbeta;3) complex called glycoprotein IIb (GPIIb). GPIIb is a calcium-dependent, no covalently associated heterodimer and contains a heavy chain (GPIIbalpha;) and a light chain (GPIIbbeta;) linked by a single disulfide bond. The CD41 antigen is restrictedly expressed by platelets and platelet precursors (megakaryocytes). CD41/CD61 complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and plays a central role in platelet activation and aggregation. The GPIIb/IIIa may be absent or strongly reduced in Glanzmannrsquo;s thrombasthenia (GT). HIP8 antibody may completely inhibit platelet aggregation and ATP secretion induced by ADP, thrombin and collagen. HIP11 may react with alpha; and beta; subunits of GPIIb/IIIa (CD41/CD61) complex./p
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h4Product Citations/h4
pnbsp;/p
pShen DC ; Chen Z ; Yu AX ; et al ; 1986.nbsp; A group of monoclonal antibodies reacted with human thymocyte differentiation antigens: production and specificity analysis. Chinese J. of Immunology. 2(6):331/p
pnbsp;/p
h4Recommended Products/h4
pbr /
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h4Alternate Names/h4
pIntegrin alpha-IIb; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; ITGA2B; GP2B; ITGAB/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P08514P08514/abr /
a class=accession-link target=_blank href=http://www.ncbi.nlm.nih.gov/protein/88758615NP_000410/abr /
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h4Clonality/h4
pHIP8/p
h4Antigen/h4
pnbsp;/p
h4Application Notes/h4
pnbsp;/p
pFACS with whole blood: 100 mu;l blood + 20 mu;l antibody; FACS with cells: 10E6 cells + 20 mu;l antibody. E: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pIF:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
pnbsp;/p
h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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