CD41 (HIP7) Antibody

h1 class=titleCD41 (HIP7) Antibody/h1
div id=node-1556 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250964/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe CD41 (HIP7) antibody recognizes a 140-kDa glycoprotein which is the alpha; subunit of the CD41/CD61 (GPIIb/IIIa, alpha;IIbbeta;3) complex called glycoprotein IIb (GPIIb). GPIIb is a calcium-dependent, no covalently associated heterodimer and contains a heavy chain (GPIIbalpha;) and a light chain (GPIIbbeta;) linked by a single disulfide bond. The CD41 antigen is strictly expressed on platelets and platelet precursors (megakaryocytes). The CD41/CD61 complex is the receptor for fibrinogen, fibronectin and von Willebrand factor, and plays a central role in platelet activation and aggregation. The GPIIb/IIIa may be absent or strongly reduced in Glanzmannrsquo;s thrombasthenia (GT). The CD41 (HIP8) antibody inhibits platelet aggregation and ATP secretion induced by ADP, thrombin and collagen. The CD41 (HIP11) antibody reacts with alpha; and beta; subunits of GPIIb/IIIa (CD41/CD61) complex./p
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h4Product Citations/h4
pnbsp;/p
pWu XW., et al. 1989. National Medical J. of China. 69(8) :427/p
pChen Z., et al. 1987. Chinese Science Bulletin. 24 :1902/p
pKnapp W., B. Dorken, E.P.Rieber, et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P:798, 1078 Oxford University Press, New York/p
pTadamitsu. K., K.Hitoshi, A.E.G.Kr.van dem Borne, et al., eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P:940, 963-968 Garland Publishing, Inc.,nbsp; New York./p
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h4Recommended Products/h4
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h4Alternate Names/h4
pIntegrin alpha-IIb; Platelet membrane glycoprotein IIb; GPalpha IIb; GPIIb; CD41 antigen; ITGA2B; GP2B; ITGAB/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P08514P08514/abr /
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h4Clonality/h4
pHIP7/p
h4Antigen/h4
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h4Application Notes/h4
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pPurified antibody is suitable for immunohistochemistry with acetone-fixed and frozen sections./p
pE: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H/p
pnbsp;/p
h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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