CD31 Antibody

h1 class=titleCD31 Antibody/h1
div id=node-1897 class=node ntype-antibodiesRabbit Polyclonal, HRP-conjugated
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h4Catalog Number/h4
pstrong252253/strong/p
h4Unit/h4
pstrong0.1 mg /strong/p
h4Isotype/h4
Rabbit Ig
h4Applications/h4
E, WB, IHC
h4Species reactivity/h4
H, M, R, Other
h4Format/h4
pnbsp;/p
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily./p
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h4Product Citations/h4
pnbsp;/p
pFeng X. et al. JASN Jul 2009/p
pnbsp;/p
h4Alternate Names/h4
pPlatelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; CPIIA'; CD31 antigen; PECAM1/p
h4Accession No./h4
pa class=accession-link href=http://www.expasy.ch/uniprot/P16284 target=_blankP16284/abr /
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PECAM1./p
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h4Application Notes/h4
pnbsp;/p
pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
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h4Storage/h4
pnbsp;/p
pStore at -20deg;C. Product is guaranteed 6 months from the date of shipment./p
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