CD20 Antibody

h1 class=titleCD20 Antibody/h1
div id=node-120 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250166/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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pnbsp;/p
Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography./p
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h4Data and Images/h4
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h4Description/h4
pThis antibody recognizes the CD20 antigen, which is a phosphoprotein with a molecular weight of 35-37 kDa depending of phosphorylation state. CD20 is only expressed on B-lineage cells concomitantly with surface IgM. The CD20 antigen is lost prior to differentiation into plasma cells. No extracellular ligand for CD20 has yet been identified. Indirect evidence suggests that CD20 functions as a B-cell calcium channel subunit. The expression of CD20 in disparate cell types generates a qualitatively similar channel activity to that found endogenously in B-cells. This is consistent with observations that CD20 regulates cell cycle progression and exists on the cell surface as a homo-oligomer. Monoclonal antibodies against CD20 are used to treat people who have B-cells non-Hodgkin's lymphoma (NHL). Various therapeutical forms of these antibodies are known as Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). The Abbiotec antibody can be used for detecting CD20 in flow cytometry./p
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h4Product Citations/h4
pnbsp;/p
pMason, D et al. (eds.), Leukocyte typing VII., Oxford University Press, Oxford (2002)/p
pnbsp;/p
h4Recommended Products/h4
pbr /
a href=http://www.abbiotec.com/antibodies/CD20-Antibody-0250167 CD20 Antibody/abr /
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h4Alternate Names/h4
plt;pgt; B-lymphocyte antigen CD20; Membrane-spanning 4-domains subfamily A member 1; B-lymphocyte surface antigen B1; Leu-16; Bp35; MS4A1; CD20 lt;/pgt;/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://au.expasy.org/uniprot/P11836P11836/abr /
a class=accession-link target=_blank href=http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=proteinamp;id=23110989NP_690605/abr /
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h4Clonality/h4
pCAT 13.6E12/p
h4Antigen/h4
pnbsp;/p
h4Application Notes/h4
pnbsp;/p
pFACS with whole blood: 100 mu;l blood + 10 mu;l antibody/p
pFACS with cells: 500,000 cells in 50 mu;l + 10 mu;l antibody/p
pThis antibody recognizes the CD10 antigen. In flow cytometry, the antibody stains 5-10% of human peripheral blood mononuclear cells./p
pstrongReacts with/strongnbsp; :H/p
pnbsp;/p
h4Storage/h4
plt;pgt; Store at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. lt;/pgt;/p
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