CD183 (Rodent) Antibody

Chemokine receptor CXCR3 (CD183) is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Binding of CXCL9, CXCL10, and CXCL11 to CD183 is able to elicit increases in intracellular Ca2++ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK). CD183 binds to CCL21 and is expressed in lymphoid organs and Th1 cells. CXCR3 has been implicated in the following diseases, atherosclerosis, multiple sclerosis, pulmonary fibrosis, type 1 diabetes, autoimmune myasthenia gravis, nephrotoxic nephritis, acute cardiac allograft rejection, and possibly Celiac Disease.