CD11b (HI11b) Antibody

h1 class=titleCD11b (HI11b) Antibody/h1
div id=node-1844 class=node ntype-antibodiesMouse Monoclonal, PE-conjugated, APC-conjugated
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h4Catalog Number/h4
pstrong251057/strong/p
h4Unit/h4
pstrong2 ml/strong/p
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Format/h4
pEach vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCD11b antibody recognizes the 165 KD integrin alpha;M-chain associated with CD18 (95KD integrinbeta;2) forming heterodimer glycoprotein called CD11b/CD18 (Mac-1). Leucocytes express four CD11/CD18 integrins which comprise a common beta;2 subunit and distinctive alpha; subunits. The other three integrins are known as CD11a/CD18, CD11c/CD18 and CD11d/CD18. Expression of the CD11b subunit on the leucocyte cell surface requires the presence of the CD18 subunit. Patients who have mutated CD18 genes do not express cell membrane Mac-1 (or the otherbeta;2 integrins), a condition known as leucocyte adhesion deficiency 1 (LAD-1), in which patients have major problems with bacterial infections. Mac-1 is most highly expressed on neutrophils and monocytes/macrophages, a subset of NK cells, and activated lymphocytes. Mac-1 operates as a phagocytic receptor, and has a role in myeloid cell transmigration and is also as a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and fibrinogen./p
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h4Product Citations/h4
pnbsp;/p
pWang MJ, et al., 1991. Changes of cytosolic Ca2+ concentration in FURA-2-Loaden human platelets induced by monoclonal antibodies HIP2, APT4, HI117 and SJ-9A4. Chinese J. of Hematology. 12(2):58/p
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h4Recommended Products/h4
pbr /
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h4Alternate Names/h4
pIntegrin alpha-M; Leukocyte adhesion receptor MO1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Neutrophil adherence receptor; CD11 antigen-like family member B; CD11b antigen; ITGAM; CD11B; CR3A/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P11215P11215/abr /
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h4Clonality/h4
pHI11b/p
h4Antigen/h4
pnbsp;/p
h4Application Notes/h4
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pFACS with whole blood: 100 mu;l blood + 20 mu;l antibody; FACS with cells: 10E6 cells + 20 mu;l antibody. E: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pIF:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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