CD11a (HI111) Antibody

h1 class=titleCD11a (HI111) Antibody/h1
div id=node-1779 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250944/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCD11a antibody recognizes the 180KD integrin alpha; chain associated with CD18 (95KD integrin beta;2) forming heterodimer glycoprotein called the lymphocyte function antigen-1 (LFA-1, CD11a/CD18). Leucocytes express four CD11/CD18 integrins which comprise a common beta;2 subunit and distinctive alpha; chains. The other three integrins are known as CD11b/CD18, CD11c/CD18 and CD11d/CD18. LFA-1 is present on all leucocytes and is responsible chiefly for adhesion between leucocytes during immune response and also functions in transmigration of leucocytes across endothelium. The ligands for CD11a/CD18 are intercellular adhesion molecules CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). Patients who have mutated CD18 genes do not express cell membrane LFA-1(or the other beta;2 integrins), a condition known as leucocyte adhesion deficiency 1 (LAD-1)./p
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h4Product Citations/h4
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pHan JS., Liao XL., Huang LH., et al, 1989. HI117: A monoclonal antibody for purging in vitro autologous marrow grafts in acute leukemia. Chinese J. of Hematology. 10(3):113/p
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h4Recommended Products/h4
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h4Alternate Names/h4
pIntegrin alpha-L; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11 antigen-like family member A; CD11a antigen; ITGAL; CD11A/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P20701P20701/abr /
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h4Clonality/h4
pHI111/p
h4Antigen/h4
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pA synthetic peptide corresponding to ..../p
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h4Application Notes/h4
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pPurified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections./p
pE: 1:500-1:1,000/p
pFACS: 1:200-1:1,000/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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