CD105 Antibody

Catalog Number

251222

Unit

0.1 mg

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

The CD105 antigen (endoglin) is a major glycoprotein of the vascular endothelium with a role in integrins and RGD receptors for endothelial cell adhesion. CD105 forms heteromeric complex with signaling receptors for transforming growth factor-beta. CD105 expression is restricted to endothelial cells in all tissues except bone marrow. Defects in CD105 are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1).

Alternate Names

CD105; Endoglin; ENG; END

Accession No.

P17813

 

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD105.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:100-1:500

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.