CCR-5 Antibody

C-C chemokine receptor type 5 (CCR-5) is a receptor for a number of inflammatory CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES. CCR-5 transduces a signal by increasing the intracellular calcium ion level. CCR-5 plays a role in the control of granulocytic lineage proliferation or differentiation. CCR-5 acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.